A team of scientists has developed a promising new strategy for "reactivating" genes that cause cancer tumors to shrink and die. The researchers hope that their discovery will aid in the development of an innovative anti-cancer drug that effectively targets unhealthy, cancerous tissue without damaging healthy, non-cancerous tissue and vital organs. The research will be published in the Journal of Biological Chemistry. (more)
A novel technique has been developed and demonstrated at Penn State to map the proteins that read and regulate chromosomes -- the string-like structures inside cells that carry genes. The specific order in which these proteins attach DNA-containing nucleosomes along the chromosome determines whether a brain cell, a liver cell, or a cancer cell is formed. Until now, it has been exceedingly difficult to determine exactly where such proteins bind to the chromosome, and therefore how they work. The new technique precisely pinpoints their location, and has the potential to take high-resolution snapshots of proteins as they regulate or miss-regulate an entire genome. The research will be published today as an Advance Online Publication in the journal Nature. Related research by the Penn State scientists recently was published in the journal Cell. (more)
Galaxy -- an open-source, Web-based platform for data-intensive biomedical and genetic research -- is now available as a cloud computing resource. A team of researchers has developed the new technology, which will help scientists and biomedical researchers to harness such tools as DNA-sequencing and analysis software, as well as storage capacity for large quantities of scientific data. (more)
Both climate change and humans were responsible for the extinction of some large, cold-adapted, plant-eating mammals, according to research that is the first of its kind to use genetic, archeological, and climatic data together to infer the population history of large-bodied Ice-Age mammals. The research will be published in the journal Nature.
The study's findings are expected to shed light on the possible fates of living species of mammals as our planet continues its current warming cycle. Beth Shapiro, the Shaffer Associate Professor of Biology at Penn State University, is a member of the research team. High-resolution images are online at
http://www.science.psu.edu/news-and-events/2011-news/Shapiro10-2011 (more)
An endangered species, Przewalski's horse, is much more distantly related to the domestic horse, and likely have a much more diverse gene pool, than researchers previously had hypothesized, reports a team of investigators led by Kateryna Makova, associate professor of biology at Penn State. The new study's findings could be used to inform conservation efforts to save the endangered horse species, of which only 2,000 individuals remain in parts of China and Mongolia, and in wildlife reserves in California and Ukraine.
The scientists tested the portion of the genome passed exclusively from mother to offspring -- the mitochondrial DNA -- of four Przewalski's horse lineages and compared the data to DNA from the domestic horse (Equus caballus). They concluded that, although previous scientists had assumed that Przewalski's horse and the domestic horse had diverged around the time that horses were domesticated -- about 6,000 to 10,000 years ago -- the real time of the two species' divergence from one another is much more ancient. (more)
The molecular mechanisms that control genetic modifications in specific tissues during plant development are the focus of a National Science Foundation grant for $1.2 million to Surinder Chopra, associate professor of maize genetics in Penn State's College of Agricultural Sciences. (more)
A revolutionary species-preservation approach based on whole-genome analyses of two Tasmanian devils -- one that had died of a contagious cancer known as Devil Facial Tumor Disease (DFTD) and one healthy animal -- has been used to develop a theoretical model to predict which individuals would need to be kept in captivity to maximize chances of preserving enough genetic diversity for the species to survive.
The research helps to formulate one possible plan of action to prevent the extinction of the Tasmanian devil -- a marsupial found in the wild exclusively in the Australian island-state of Tasmania. The research model also may be extended to other endangered species. (more)
Scientists at Penn State have used large-scale DNA sequencing data to investigate, for the first time, a longstanding evolutionary assumption: that DNA mutation rates are influenced by life-history traits, including metabolic rate and the length of time between generations. The research team found, for example, a higher rate of DNA mutations in the male sperm versus the female egg. One of the many implications of this research is that life-history traits of extinct species now could be discoverable. (more)
Scientists at Penn State have achieved a major milestone in the attempt to assemble, in a test tube, entire chromosomes from their component parts. The achievement reveals the process a cell uses to package the basic building blocks of an organism's entire genetic code -- its genome. The evidence provided by early research with the new procedure overturns three previous theories of the genome-packaging process and opens the door to a new era of genome-wide biochemistry research. A paper describing the team's achievement will be published in the journal Science on May 20. (more)
A massive database cataloging the human genome's functional elements -- including genes, RNA transcripts and other products -- is being made available as an open resource to the scientific community, classrooms, science writers and the public, thanks to an international team of researchers. In a paper published in the journal PLoS Biology on April 19, the project -- called ENCODE (Encyclopedia Of DNA Elements) -- provides an overview of the team's ongoing efforts to interpret the human genome sequence, as well as a guide for using the vast amounts of data and resources produced so far by the project. (more)
